Leider kann ich den Text nicht übersetzten. Allerdings ist mir aufgefallen, er ist Copyright 2018, was ja in der MM Behandlung eine andere Welt ist.

Verstehe auch nicht, was dieser Artikel in diesem Tread soll, kann natürlich daran liegen, dass ich ihn nicht wirklich verstehe.

Studie aus PubMed

High-dose zinc oral supplementation after stem cell transplantation causes an increase of TRECs and CD4+ naïve lymphocytes and prevents TTV reactivation

Lorenzo Iovino 1 , Francesco Mazziotta 2 , Giovanni Carulli 2 , Francesca Guerrini 2 , Riccardo Morganti 3 , Valentina Mazzotti 3 , Fabrizio Maggi 4 , Lisa Macera 4 , Enrico Orciuolo 2 , Gabriele Buda 2 , Edoardo Benedetti 2 , Francesco Caracciolo 2 , Sara Galimberti 2 , Mauro Pistello 4 , Mario Petrini 2
Affiliations expand
PMID: 29747074 DOI: 10.1016/j.leukres.2018.04.016
Abstract

Introduction: Zinc plays an important role in thymic function and immune homeostasis. We performed a prospective clinical trial using a high-dose zinc oral supplementation to improve the immune reconstitution after hematopoietic stem cell transplant (HSCT).

Patients and methods: We enrolled 18 patients undergoing autologous HSCT for multiple myeloma. Nine patients were randomized to receive only a standard antimicrobial prophylaxis; whereas, nine patients received in addition 150 mg/day of zinc from day +5 to day +100 after transplant.

Results: CD4+ naïve lymphocytes and TRECs showed a significant increase from day +30 until day +100 only in the zinc-treated group. Moreover, the load of Torquetenovirus, a harmless virus that replicates in course of immunedepression, increased at day +100 only in the control group. No severe adverse events were reported during the zinc consumption.

Conclusion: First data from the ZENITH trial suggest that high-dose zinc supplementation is safe and may enhance the thymic reconstitution after HSCT. Registered: Clinicaltrials.gov (NCT03159845); and EUDRACT: 2014-28 004499-47.

Keywords: Bone marrow transplant; Digital PCR; Immune reconstitution; Immunesenescence; T cell; TTV; Thymus; Zinc.

Copyright © 2018 Elsevier Ltd. All rights reserved.

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